Please select the option that best describes you:
Do you still recommend protons for grade 2 and grade 3 glioma, following the Soprano study results showing a survival detriment?
Recently presented in abstract form at SNO 2025.
Answer from: Radiation Oncologist at Academic Institution
I should start by saying that I generally do not recommend proton therapy for grade 2-3 gliomas in adults unless there is a clear and specific indication. Modern photon techniques such as VMAT are highly conformal, efficient, and safe, and they form the backbone of the evidence base that guides our ...
Sign In or Register to read more
Answer from: Radiation Oncologist at Academic Institution
Proton therapy is generally considered less deleterious (harmful) than traditional photon radiation for brain tumors. In this non-randomized study from the Netherlands and Belgium, 373 consecutive patients (256 with WHO grade 2 IDHm gliomas and 117 with WHO grade 3 IDH gliomas) were treated postoper...
Answer from: Radiation Oncologist at Community Practice
The APPROACH study in the UK, which is a randomised study for grade 2 and 3 oligodendroglioma looking at neurocognitive effects with PBT vs X-rays, has temporarily closed accrual to the grade 3 arm of the trial following publication of this abstract.However, as outlined above by Dr. @Stea, it would ...