Do you time initiation of definitive radiation on PSA response to neoadjuvant ADT?

In the setting of definitive RT, I will generally wait 2-3 months before beginning radiation for 2 reasons. First, during that period of time the prostate may shrink by as much as a third of it's original size, which may adversely impact on the normal tissue dosimetry if this were to occur during th...

I would agree with @Dr. First Last in regard to timing. Practically speaking, in the US most RTOG studies started 2 months prior to RT. In Canada and Australia this could have been 6 or 8 months prior to RT, and in EORTC at the same time as RT. Nevertheless, 2-3 months is useful for volume reduction...