I don't understand the design of these "PO vs IV" abx trials. RCTs, of course, are done to minimize the differences between the experimental and control groups. Hopefully, through randomization, the only significant difference will be the "experiment" or treatment. However, in this and most "PO" stu...

I agree with Dr. @Smith, further these are tissue drugs more than bloodstream drugs. That’s why they don’t work well in bacteria.

I agree with Dr. @Smith's comment on the selection of oral antibiotics. The secondary endpoints cannot be analyzed as only 3-4% of patients screened were enrolled/not powered to assess. As per the Supplementary material, the number of patients who received Cotrimoxazole, Clindamycin, and Linezolid w...