Topics:
Neurology • Neuromuscular
Do you treat patients with riluzole who have ALS and a valosin-containing protein mutation?
Does your management change in any way?
Answer from: at Academic Institution
Yes. Riluzole is a glutamate antagonist; motor neuron damage due to glutamate-related excitotoxicity is a theme in ALS pathophysiology regardless of the genetic mutation that may cause ALS. Based on this, and the lack of any available VCP-specific treatments, I see no reason not to offer riluzole in...
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