Do you typically see peripheral neuropathy in patients with castleman syndrome?

Castleman's is a rare disorder. It has been associated with POEMS in which severe neuropathy is part of the syndrome, but is not as common an association as myeloma. But neurologists only see the patients who have neurologic symptoms. My brief look at review articles on Castleman's suggests that POEMS is not a common occurrence in Castleman's. Other neuropathies are not mentioned.

The key clinical point is that if a patient has a severe neuropathy, and M protein with lambda light chain, with or ...

I treated a patient for Castleman's disease who developed severe neuropathy without any of the other features of POEMS. We treated him with high-dose steroids, IVIG and siltuximab, and intensive inpatient therapy. With this combination has made a full recovery and continues to receive siltuximab maintenance.

Lust et al., PMID 34302703