Castleman's is a rare disorder. It has been associated with POEMS in which severe neuropathy is part of the syndrome, but is not as common an association as myeloma. But neurologists only see the patients who have neurologic symptoms. My brief look at review articles on Castleman's suggests that POE...

I treated a patient for Castleman's disease who developed severe neuropathy without any of the other features of POEMS. We treated him with high-dose steroids, IVIG and siltuximab, and intensive inpatient therapy. With this combination has made a full recovery and continues to receive siltuximab mai...