Do you use an antibiotic with antitoxin activity for the entire duration of therapy for patients with necrotizing MSSA or MRSA pneumonia or just until definitive clinical improvement?  

I misread the question. I assumed a necrotizing S. aureus infection meant a necrotizing skin and soft-tissue infection. I’m not sure how “necrotizing pneumonia” is being defined here. Regarding MRSA pneumonia with toxin-mediated tissue injury, there are data suggesting that linezo...

I use targeted therapy to the organism identified; if I do not have an organism yet and the patient has appropriate risk factors for MRSA necessitating empiric coverage, I do favor linezolid but specifically for its data in pneumonia and not its use in necrotizing fasciitis/toxin data. Once I have a...