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What drug and specific dosing would you use for secondary pneumocystis prophylaxis in a patient with renal transplant, documented TMP-SMX allergy, and normal G6PD testing, who was diagnosed with moderate PJP and improved on clindamycin/primaquine and steroids?

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Mednet Member
Mednet Member
Infectious Disease · National Institute of Allergy and Infectious Diseases (NIAID)

I think the options are dapsone (which is tolerated by most patients allergic to TMP/SMX), atovaqone, and inhaled pentamidine. During my career, those choices have depended to some extent on the local practice. I have preferred inhaled pentamidine because I have worked in places with low volume and ...

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Mednet Member
Mednet Member
Infectious Disease · Maricopa County Correctional Health Services

Dapsone and Atovaqoune only, inhaled pentamidine efficacy is <80% for PCP prophylaxis in older literature.

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