Do you use any particular dose constraints in patients receiving whole-brain radiation in the setting of prior SRS?

If a patient remains a candidate, I prefer to offer hippocampal sparing WBRT whenever possible, respecting the hippocampal constraints outlined in RTOG 0933 (Hippocampus D100% <= 9Gy; dmax <16Gy).

In terms of other dose constraints, I don't typically enforce any constraints that would impact the coverage of the remaining CTV. For modulated HA-IMRT plans, I would make sure no hotspots are within the optics or brainstem.

I tend to think about this situation as the reverse of RTOG 9005, which was SRS...