Do you use IL-1 inhibitors to prevent flares of gout or CPPD in patients who experience flares despite prophylaxis with colchicine, NSAIDs, and/or low-dose prednisone?

Topics: Rheumatology • Crystal Arthritis • RheumMadness

Answer from: at Academic Institution

I have used IL-1 inhibitors to control gout flares or gout flare recurrences in patients who have been refractory to standard gout flare or gout flare prophylaxis management. Likewise, on extremely rare occasions, I have used an IL-1 inhibitor for recurrent CPPD flares, though with mixed results.The...

Comments

at Baton Rouge Clinic
Would you try methotrexate or leflunomide since IL...

at George Washington University
No, not for gout flares. TNF inhibitors don’...

Answer from: at Academic Institution

I agree completely with Dr. @Baraf. While one shouldn't define practice solely by anecdote, I have had several unfortunately refractory crystal-arthritis patients who had marked response to IL-1 inhibitors, including a patient who had dramatic improvement within 24 hours of starting Anakinra for a h...

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