Do you use minimum cutoff values for any PFTs below which you would not offer conventionally fractionated chemoradiation or SBRT for NSCLC?

We have historically not used a cut-off lower-limit for FEV1 or DLCO when selecting patients for SBRT for stage I NSCLC. This is supported by both our own (PMID 19487961) and the Indiana University (PMID 18394819) series in which patients were divided into quartiles by baseline PFT's. In both series...

The beauty of SBRT is that there are no PFT cutoffs and even patients who require oxygen via nasal cannula are candidates. That being said, my experience is that these oxygen-dependent patients are the ones that are more likely to run into complications with radiation pneumonitis or decline in respi...

No.