Do you use prophylactic defibrotide in pediatric patients undergoing BMT who are considered to be at high risk for the development of VOD/SOS?

Prophylactic defibrotide can indeed be used in pediatric patients undergoing bone marrow transplant (BMT) who are considered to be at high risk for the development of veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS).

Studies, including those leading to defibrotide’s FDA approval for V...

Yes, I routinely use prophylactic defibrotide for pediatric patients with high-risk features based on the results of the pediatric trial in Europe, meta-analysis and institutional experience. Perhaps the clearest indications are children with osteopetrosis, HLH, and MPS disorders as they have very h...