The osmotic diuresis induced by SGLT2 inhibitors results in the urinary excretion of water in excess of Na+ and K+ excretion, thereby resulting in an increase in the serum sodium concentration. However, SIADH is a clinical disorder characterized by an increase in TBW in the setting of relatively nor...
I have utilized SGLT2 inhibitors in the management of SIADH in the past. As Dr. @Nguyen mentions, the natriuresis associated with SGLT2 inhibitors, but it doesn't lead to a durable natriuresis (likely because of its effect early in the tubule) compared to say loop diuretics (ie that's why we use loo...
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at UCLA SGLT2 inhibitors may not lead to a durable natriur...