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Topics:
Allergy & Immunology • Mast Cell Disorders
Do you use Xoliar as add-on treatment for hereditary alpha tryptasemia?
Answer from: at Community Practice
No.
Alpha Tryptase is released without mast cell degranulation triggered by an IgE/antigen reaction; hence, neutralizing IgE would not have any beneficial effect.
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Answer from: at Academic Institution
Hereditary alpha-tryptasemia (HaT) is a genetic trait rather than a syndrome or disease. HaT occurs when there is one or more tandem extra copies of the TPSAB1 alpha allele on one or both chromosomes and results in individuals having serum tryptase values that are higher than the reference range. I ...