Do you use Xoliar as add-on treatment for hereditary alpha tryptasemia?

No.

Alpha Tryptase is released without mast cell degranulation triggered by an IgE/antigen reaction; hence, neutralizing IgE would not have any beneficial effect.

Hereditary alpha-tryptasemia (HaT) is a genetic trait rather than a syndrome or disease. HaT occurs when there is one or more tandem extra copies of the TPSAB1 alpha allele on one or both chromosomes and results in individuals having serum tryptase values that are higher than the reference range. I do not use omalizumab (Xolair) or any other medication as a treatment for the HaT genetic trait. More research is needed to determine whether tryptase proteins in their tetrameric or monomeric forms c...