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Does a negative staging PSMA PET in a patient with biopsy-proven recurrent prostatic adenocarcinoma change your management?

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Mednet Member
Mednet Member
Radiation Oncology · University of British Columbia

The bottom line is that you have to believe the biopsy. PSMA PET will not show microscopic disease, which is why it cannot "rule out" disease in lymph nodes or elsewhere. It is comforting when it is negative, but it is not absolute truth.

A few questions; What was the PSA at the time of the PSMA PET...

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Mednet Member
Mednet Member
Radiation Oncology · Varian Medical Systems/Allegheny health network

The concordance between PET and MRI for recurrence is about 50%.

Valle et al., Journal of Clinical Oncology 2023

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