Does being on maintenance pembrolizumab change how you manage patients with partial metabolic response on PET/CT 3 months after chemoradiation for cervical cancer?

No, a good percentage of patients will not have a complete response by 3 months. Six months seems to be a reasonable cutoff. Persistent disease at 3 months does not seem to be a worse prognostic factor than completion at 6 months. At the 3-month mark, I would not manage differently. At 6 months, I w...

I would still add MRI with DWI sequence to decide the next step. If negative, continue the same but if positive, consider biopsy and plan salvage accordingly.

Kalash et al., PMID 29559287