Does germline BRCA 1/2 mutation status impact your use of OncoType Dx for early stage ER positive breast cancers in post-menopausal women?
Would you offer adjuvant chemotherapy to a post-menopausal woman with a BRCA2 mutation and a T2N0 ER positive breast cancer with an oncotype of 12?
Answer from: Medical Oncologist at Community Practice
Germline BRCA1/2 associated tumors tend to have higher grade and higher Oncotype recurrence score (RS). One of the reported studies out of MSKCC showed higher median Recurrence Score (RS) for mutation carriers versus controls (24 vs 16; P < .0001). Since RS is both prognostic and pr...
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