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Does receiving IVIG confound the result of SPEP and/or UPEP?

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How do you interpret SPEP/UPEP in the setting of recent IVIG use?

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2 Answers
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Hematology · John Theurer Cancer Center Hackensack Univ Med Center
Answered on

IVIG being a product of polyclonal immunoglobulins may ‘produce’ a monoclonal spike if the AUC is falsely calculated by the reader. IFE usually shows polyclonal banding but every now and then a monoclonal band is picked up. Being an IgG molecule with a 21 day halflife; and with the assumption that i...

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Neurology · Cedars-Sinai Medical Center
Answered on

Checking for IgG antibodies while on IVIg can give false positives. Hep C antibodies, ANA, and related results are often misinterpreted when drawn on IVIg. Waiting at least 6 weeks would be the optimal.

Also, sed rates will be very elevated with IVIG. Generally, it is best to do as much of your auto...

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