Does the presence of ANCA antibodies in patients with newly diagnosed lupus nephritis alter your approach to management?

I've never encountered this, to be honest, but I've always worried about what I would do, since a fair percentage of patients with lupus are reported to have ANCA antibodies thought to have no clinical relevance.

The problem is the "pauci-immune" part of ANCA-associated GN, so that there is no "positive" pathognomonic finding. I've seen several patients in which MPA or GPA was missed because the GN was incorrectly ascribed to IgA nephropathy - which was true on biopsy but not relevant to the cre...