Does the presence of interstitial cystitis disease affect your decision to offer post prostatectomy salvage radiation therapy?

The existence of pre-existing interstitial cystitis does not change my recommendations for 1) the need for salvage RT, or 2) the dose/volume. Certainly this man would not be ideal for adjuvant post-operative RT, but with the results of RADICALS and RAVES, adjuvant post-operative RT should be offered in very limited circumstances.

In the salvage setting, we know that there is PSA recurrence and that salvage PORT improves cancer outcomes, including overall survival (SWOG, RTOG 9601). Therefore it i...