Does the presence of signet ring or mucinous pathology alter your management of stage 2 colon cancer?

In general, both portend a worse prognosis. For stage II the benefit of chemotherapy is modest. I would strongly encourage considering the COBRA study if patient is stage IIA. https://clinicaltrials.gov/ct2/show/NCT04068103. Note that eligibility requires adenocarcinoma. I would do more frequent fol...