Thank you for this question. There have been publications that have shown the association of ADT and cognitive decline. Probably one of the most robust studies was published in 2017 (Nead et al., PMID 27737437) in which the effect of ADT on dementia risk was assessed using propensity score-matched m...

Over the first ~5 years, ADT primarily improves bRFS in my opinion. Any improvement in hard clinical endpoints such as metastasis free and overall survival trails that, often significantly (especially considering that we are getting better at "pounding down" relapse, should it occur). My understan...

I would discuss the option of bicalutamide 50 mg TID as an alternative to LHRH agonists due to much better tolerability and similar efficacy (Iversen et al., PMID 11025708) esp in these patients adjusted for life expectancy and risk of suffering from cancer progression during their remaining years. ...