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In platinum-refractory or multiply-relapsed NSGCT with 1–2 progressive sites and no good surgical option, is there a role for local radiotherapy (e.g., SBRT) to those sites?

If considered, what clinical selection (marker status, histology/teratoma concern) and goals (local control vs palliation) do you use? Suggested dose/fractionation and organs-at-risk constraints? Does your approach differ for brain vs extracranial oligoprogression?
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Would you offer RT for multiply-relapsed NSGCT with oligoprogressive disease (<2-3 sites) and no surgical options?

118 physicians have voted

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