For a patient with carcinosarcoma of the uterus and an allergic reaction to paclitaxel, would you have any reservations about using docetaxel instead?

While there is no clear data for this in carcinosarcoma, Yes, I would be comfortable using Docetaxel in this scenario. I am extrapolating from ovarian cancer, where the two drugs have similar activity; The SCOTROC trial in ovarian cancer compared Carbo-Paclitaxel vs. Carbo-Docetaxel and found similar activity. Given carcinosarcoma is likely epithelial in origin and we know Carbo-paclitaxel is active in epithelial uterus, carbo-docetaxel is also likely similarly active.

It is important to note a...