For a patient with concurrent diagnoses of Hodgkin Lymphoma and Light Chain Myeloma complicated by Myeloma Kidney, how would you approach treatment?

I have seen this once, just once. Two separate but newly diagnosed hematologic malignancies that require treatment simultaneously are rare. More common is a passenger MBL in a myeloma older than 70 y.o., MGUS in the setting of another lymphoid malignancy is not unheard of, and a T-cell gene rearrangement false positive a few times a year is almost mandatory for many centers. This is just a note to be absolutely sure the diagnosis is correct and both cancers need treatment simultaneously; otherwi...

This is a tough case for sure and something I've only seen in our VA population - still very rare.

"Myeloma kidney" can mean any number of things, so I think a second-opinion pathological review of all slides - kidney, lymph node, BMBx, etc. - is imperative to make sure the right diagnoses are being invoked. If all of these are confirmed, I agree with @Dr. First Last about treating the one that's "burning brightest" first.

That being said, to your specific question, there's definitely overlap bet...