For a very high risk prostate cancer with relatively no elevation in PSA but no distant or nodal metastasis would you consider “neoadjuvant” ADT and chemotherapy prior to EBRT?

Topics: Genitourinary Cancers • Prostate Cancer • Medical Oncology

In this case, Gleason 5+5 in all cores, clinical T4.

Answer from: Medical Oncologist at Academic Institution

This is a very challenging scenario in dealing with men who have M0 N0 but very high risk disease with a Gleason 10 (grade group 5) locally advanced tumor. Recent data supports a very poor outcome for these low PSA high grade patients when treated with IMRT and ADT alone (Mahal BA et al Eur Ur...

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Medical Oncologist at Bon Secours Saint Mary's Hospital
Thank you for your detailed response I was thinki...

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