For biochemical failure following prostatectomy, is there a PSA value that would be considered too high to offer local salvage radiotherapy?

While I don't advocate an absolute PSA cut-off for offering salvage RT, the evidence would suggest that the higher the PSA, the lower the chance of success, especially for higher grade tumors. Patients with PSAs above 2 or so appear to have a poor prognosis with RT alone, but I would not consider th...

I agree with @Dr. First Last. I would not apply a PSA cut-off. Patients with high PSAs after prostatectomy that rise very slowly and have positive margins can be completely salvaged even when their PSA is above 2 or even higher. In those patients, an MR to look for gross disease is critical as doses...

The RTOG 9601 study will soon present it's updated analysis, and for those who can't recall, it included pts with a rPSA of up to 4 ng/mL. They should now have >10y of follow-up to provide us all with some highly meaningful data to better understand how well pts with high rPSA values can do with sal...