Mednet Logo

For cisplatin ineligible patients with locally advanced head and neck cancer, would you consider RT + immunotherapy rather than RT + cetuximab?

In light of recent trials showing no difference in outcomes with RT+cetuximab vs RT+IO, does this potentially lead us to use immunotherapy in cisplatin-ineligible patients? IO is typically easier to administer and manage than cetuximab. Can we extrapolate this from the trials? (GORTEC 2015-01) NRG-HN004
1 Answer
Mednet Member
Mednet MemberInvited Expert
Radiation Oncology · Emory University
Answered on

No. While the cited GORTEC trial showed pembrolizumab was no worse than cetuximab, the results from HN004 showed a significant reduction in PFS in the durvalumab arm. This plus emerging data from the lab of @Dr. First Last (Darragh et al., PMID 36385142) showing that elective nodal radiation signifi...

Join for free or sign in to see the full answer