This is an interesting question. Assuming this is regarding ER positive but HER2 negative tumors, the factors I would consider that would favor the decision to use upfront chemotherapy are the following: 1. Tumors that are grade 3 or high Ki-67 2. Low ER positive tumors 3. Younger, premenopa...

I agree with the eloquent answer from @Bhuvaneswari Ramaswamy.I do exercise caution in doing Neo-adjuvant chemotherapy for ER positive, Her 2 Negative ( Luminal A) cancer outside of T3/4 or N2/3 disease.Need for chemotherapy in ER positive T2N1 disease can't be ascertained without genomic assays. &n...

if Her-2 NEU positive would definitely do neoadjuvant therapy , as if residual disease at end of neoadjuvant would be eligible for futher anti her-2 neu therapy