Do you recommend concurrent chemotherapy with XRT for inoperable patients with stage I-II high-risk endometrial carcinoma?

For inoperable patients due to medical comorbidities, we have been reluctant to add chemotherapy because of the concern about side effects. For inoperable patients due to disease extent, we routinely add concurrent chemotherapy.

https://www.ncbi.nlm.nih.gov/pubmed/25218303/

We do add chemotherapy to definitive radiation therapy for the treatment of some patients with inoperable endometrial cancer despite the lack of level 1 evidence. One rationale is that chemotherapy will increase the regression of bulky disease within the cervix and uterine body which will improve brachytherapy dosimetry. It may also be useful to add chemotherapy for high-grade histologies to reduce the risk of subsequent distant metastasis, although that benefit is unproven in this setting. For ...