For locally advanced rectal cancer, will the recent update of RAPIDO lead you to change your practice when approaching TNT?

Specifically, will the higher rate of local failure in the TNT (short-course RT) arm lead you to consider a TNT approach with long-course CRT?

Dijkstra et al., PMID 36661037

Answer from: Radiation Oncologist at Academic Institution

We prefer long course chemoradiation followed by consolidation with FOLFOX and non-operative management based on the OPRA trial, which reported 60% versus 40% using this sequence versus initial chemotherapy.

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Radiation Oncologist at Radiant Oncology
Do you consider starting with chemotherapy, then c...

Answer from: Radiation Oncologist at Community Practice

There are a number of subtleties regarding risk factors and their association with competing risks of distant vs locoregional relapse that influence my decision-making regarding short vs long course and in some capacity, sequence of therapies. I do use short course quite frequently (~60% I’d e...

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Radiation Oncologist at Texas Oncology-Arlington Cancer Center North
If not planning for non-operative management, is t...

Radiation Oncologist at Emory University School of Medicine
We prefer to sequence patients with chemoradiother...

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For locally advanced rectal cancer, will the recent update of RAPIDO lead you to change your practice when approaching TNT?

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