For marginal recurrences of skin cancers after prior hypofractionated radiation therapy (i.e., 30 Gy/5 fx, 55 Gy/20 fx) where there is concern for overlapping fields, could reirradiation with a hypofractionated course be considered?

For a marginal recurrence of a cutaneous malignancy after definitive hypofractionated RT, I would not necessarily offer reirradiation. I would have my plastic/dermatologic surgeon see the patient for consideration of surgical salvage, which may likely require an advanced reconstruction. If the patie...

As Dr. @Dr. First Last suggested, cut the failure out; likely it is small, so the cosmetic defect is likely minimal or could be reconstructed. Assess for further radiotherapy from that resection's pathology and consider adjuvant systemic therapy. The C-POST Trial, a phase 3, randomized, placebo-cont...