For multiple myeloma, is 8 Gy in 1 fraction an appropriate palliative dose, although this histology was excluded from trials examining a single fraction?

There was a randomized trial comparing 8 Gy/1 fx vs 30 Gy/10 fx for patients with multiple myeloma.

There was no difference in analgesic response or recalcification, however patients with the protracted regimen seemed to have a benefit in terms of QOL. However, the the control arm (30 Gy in 10), there were younger patients (<65 yo was 43% vs 23%) and more vertebral lesions (71% vs 42%). It may be that younger patients or patients with spinal lesions benefit from the higher BED, or it may be spu...