For patients receiving TNT for locally advanced rectal cancer who have received chemotherapy prior to chemoradiotherapy, do you treat the pre or post-chemotherapy volume for the boost, especially in patients who have had a near complete response?

I base my boost volume upon the pre-chemotherapy extent of gross disease. Times I have selectively deviated from this are almost exclusively related to unfavorable normal tissue anatomy (i.e., significant volume small bowel deep in the pelvis) such that covering the initial extent in the boost volum...