For patients starting Pluvicto, do you have patients stop their ARPI?
Answer from: Radiation Oncologist at Community Practice
While the VISION trial allowed for concomitant use, it was only about half (53%) in the Lu-177-PSMA arm, and 2/3 (68%) of those on the standard of care arm - Garje et al., PMID 36693228. And the PSMAfore trial did not, as noted above by @James Janopaul-Naylor.The bigger question is, will you continu...
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Radiation Oncologist at First Health-Moore Regional Hospital Is it possible that continuing an ARPI could inter...
Radiation Oncologist at Seton Cancer Institute I agree with you, but one could ask the same quest...
Radiation Oncologist at University of Missouri at Columbia, Ellis Fischel Cancer Cener @Stephen C. King, ARPI can upregulate PSMA express...
Answer from: Radiation Oncologist at Academic Institution
From the PSMAfore trial, ARPI was not allowed concurrently with Pluvicto. Notably, these were patients with prior exposure to at least one ARPI (inclusion was "eligible for a change in ARPI")Permitted and prohibited concomitant treatments:Androgen deprivation therapy was continued, and concomitant s...
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Radiation Oncologist at Firelands Regional Medical Center The Vision trial allowed ARPI; however, it is an o...
Is it possible that continuing an ARPI could inter...
I agree with you, but one could ask the same quest...
@Stephen C. King, ARPI can upregulate PSMA express...