For patients who require aggressive debulking in multiple myeloma, what is your preferred chemotherapy regimen and why?

I prefer VDPACE or KDPACE +/- lenalidomide, for EMD and aggressive myeloma! Our team has good data retrospectively even in patients heavily treated and who are triple RRMM.

There are no prospective data, but happy to collaborate to seek retrospective data to compare efficacy and safety in this popul...

I don’t think you will find any convincing data to guide any particular approach.
It’s important to note that VD-PACE like regimens, while effective in many ‘hairy’ circumstances, are quite toxic and the decision to move ahead should not be taken likely.

The usual situation where I might employ such...