For patients with locally advanced rectal cancer who desire organ preservation and cannot tolerate oxaliplatin, the appropriate treatment approach would be neoadjuvant, long-course radiotherapy combined with fluoropyrimidine-based chemotherapy.  After neoadjuvant treatment,...

It will depend on the extent of the disease. CRT with 5-FU/LV can achieve organ preservation in appropriately selected patients (Habr-Gama et al., PMID 30870223). I would like to add systemic chemo if bulky disease (T4 tumors, N2 disease), EMVI, etc. However, patients should be counseled that NOM is...