For patients with peritoneal carcinomatosis and minimal response to neoadjuvant chemotherapy, is there a benefit to palliative cytoreductive surgery followed by whole abdominal radiotherapy?

The prognosis for individuals with peritoneal carcinomatosis is generally bleak. Administering radiation therapy to manage gastric, colon, or appendiceal cancer is exceptionally challenging due to the imperative to safeguard the delicate large and small intestine. One potential exception arises when...

I cannot think of a scenario I would ever recommend whole abdominal radiotherapy in any GI primary with peritoneal disease.

Appendiceal carcinoma generally would be a consideration for surgery + HIPEC. Post-debulking HIPEC is being investigated in other GI primaries (and ovarian/primary peritoneal) a...