For patients with resected colon cancer, to what extent would you adapt adjuvant chemotherapy if ctDNA results don't correspond with your initial treatment recommendation?

Topics: Gastrointestinal Cancers • Medical Oncology • Colorectal Cancer • ctDNA

Answer from: Medical Oncologist at Academic Institution

Data in this field is evolving quickly. We will have more answers in the upcoming months as BESPOKE, SU2C MGH, more follow-up on PEGASUS presented at ESMO a few weeks ago, as well as CIRCULATE-JAPAN and CIRCULATE-US accrue and read out.Till that, the strongest evidence would be from what happened to...

Comments

Medical Oncologist at Hematology Oncology Consultants
Dr. @Kasi: Regarding the poll question, when do yo...

Medical Oncologist at Weill Cornell Medicine
I tag along with my colorectal surgery colleagues ...

Medical Oncologist at NYU Long Island School of Medicine
Important to note that Dr. @Kasi is raising the po...

Answer from: Medical Oncologist at Academic Institution

Addressing each of the posed scenarios individually: If you had recommended 6 months 5-FU and the initial ctDNA is positive, do you transition to a doublet?There is no data yet to use ctDNA to change your treatment recommendations and would still strongly urge clinical trials. Caution must also b...

Answer from: Medical Oncologist at Community Practice

This is a complex and evolving space and currently, we do not have sufficient data to provide high-level evidence of treatment decisions with ctDNA. That being said, in addition to what Dr. @Kasi and Dr. @Parikh have noted, a few practical considerations to take into account: If you had recommended...

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