I think the question should be, should you be testing ctDNA post adjuvant therapy? I do not want to order a test and then not know what to do with a positive result. I can imagine that this would cause fear and panic in certain patients.

For me the answer would be a clinical trial: We have the ACT-3 study open at Cornell alongside MGH (Dr. @Aparna R. Parikh's Study). It gives BRAF, HER2, Immunotherapy for MSI-High, and FOLFIRI or observation for ctDNA+ post adjuvant. ELI-002 vaccine study is an option open at multiple sites (Cor...

I think that in a motivated patient with positive ctDNA after adjuvant chemotherapy, evaluation for clinical trial is appropriate. In my opinion, I think that in the near future we will be discussing ctDNA rather than CEA as follow-up of our colon patients. In a patient in this setting who is not a ...