For pediatric patients with iron overload (high ferritin and transferrin saturation), do you perform HFE screening first, or proceed to non-HFE gene sequencing upfront to evaluate for HJV mutation as well?

When do you consider non-HFE gene testing in children with iron overload of unclear etiology?

• Upfront in all pediatric patients
• When HFE testing is negative
• Patients with very high transferrin saturation and ferritin
• Patients with cardiac or endocrine manifestations
• Confirmed hepatic iron overload
• Hepcidin defiency phenotype
• Other