For pre-menopausal patients with high-risk ER+ disease, and who desire pregnancy, what is the best time frame to pause endocrine therapy to allow for pregnancy?

Evidence suggests that pregnancy after a breast cancer diagnosis, even among women with hormone positive tumors, does not increase the risk of recurrence, however this has not been prospectively studied. Current guidelines suggest waiting 2 years, however this is based on retrospective data, that is confounded by patients risk of recurrence. There is an ongoing NCTN clinical trial that will address this question - Pregnancy Outcome and Safety of Interrupting Therapy for Women With Endocrine Resp...