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In patients with newly diagnosed HER2+ early breast cancer, what do you anticipate will become the standard sequencing for T-DXd, neoadjuvant (DB11) or adjuvant (DB05) treatment?
Or would you wait for other information/data before incorporating T-DXd in perioperative treatments? Harbeck et al., PMID 41130363
Answer from: Medical Oncologist at Community Practice
Trastuzumab deruxtecan (T-DXd) is currently recommended in the adjuvant setting for patients with residual invasive disease after neoadjuvant therapy, based on the DESTINY-Breast05 trial, while its use in the neoadjuvant setting remains investigational. Ongoing neoadjuvant trials are evaluating T-DX...
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