For pregnant nontransfusion dependent beta thalassemia patients, when would you consider ESAs for worsening anemia?
Is there a specific hemoglobin threshold at which you consider ESAs? Do you prefer observation to see if the patient autocorrects towards delivery if not needing blood transfusions?
1 Answer
Mednet MemberInvited Expert
Pediatric Hematology/Oncology · Weill Cornell Medical College
Answered on
Non-transfusion-dependent thalassemia (NTDT) patients tend to have elevated erythropoietin (EPO) levels already, proportionate to their degree of anemia. The basic pathophysiology of thalassemia is ineffective erythropoiesis (IE), in which proliferation, in response to high EPO levels, is already su...
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