Given some of the theoretical relationship between glutamate and OCD, do you ever consider the use of NMDA (or AMPA) antagonists for the treatment of refractory OCD?

2 Answers

Mednet Member

Psychiatry · Massachusetts General Hospital (MGH) and Harvard Medical School (HMS)

We recently published a systematic review and meta-analysis on glutamate-modulating agents in the treatment of OCD as augmenting agents to SSRIs or as monotherapy. Overall, we found that glutamatergic medications led to significant improvement (statistically and clinically) in OCD symptoms. We also ...

Mednet Member

Psychiatry · Morton Hospital, Brown University Health

I will consider ketamine now as my results with amantadine and memantine have not been as significant.

Given some of the theoretical relationship between glutamate and OCD, do you ever consider the use of NMDA (or AMPA) antagonists for the treatment of refractory OCD? | Mednet