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Given the results of the recently published GETUG 16 randomized trial, should all men undergoing salvage prostate radiotherapy receive concurrent hormone therapy?

In this trial, 6 months of concurrent LHRH agonist therapy improved 5-year progression-free survival from 62% to 80%, with similar benefit in low-risk (Gleason <8, PSADT >6 months, surgical margins-positive and SV invasion-negative) and high-risk (all other) patients. There was no difference in quality of life, G3+ acute toxicity or any grade late toxicity. Is any subgroup of men favorable enough to be treated with RT alone? Should at least short-term ADT be recommended, since it does not significantly affect QOL or toxicity (except G1-2 acute)?
1 Answer
Mednet Member
Mednet MemberInvited Expert
Radiation Oncology · Cedars-Sinai Medical Center
Answered on

I'm not surprised to see this question posted on The Mednet. GETUG 16 was recently published (Lancet Oncol. 2016 May 6.) and provides additional prospective information regarding the role of ADT in the managment of salvage prostatectomy cases. Not to nitpick over the article excessively, but I did n...

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