Has use of PSMA PETCT revealed increased local failures than previously known after definitive prostate EBRT with biochemical failure?

Prior to the advent of PET imaging, the published rates of local recurrence (LR) after definitive RT vary widely in phase III trials from ≈ 1% (e.g., PCS IV) to ≈ 30% (e.g., PROG 9509). The heterogeneity is likely explained by several factors including (1) differences in baseline risk of local recur...

Yes

Anecdotally, with > 300 institutional PSMA scans, yes. MpMRI is still good for prostate since renal excretion of PET tracer limits sensitivity.