Have the growing reports about doxycycline resistance in gonorrhea isolates from patients prescribed doxy PEP for prevention of bacterial STIs influenced your use of doxycycline for this indication?

No, they have not. For 2-3 decades, the prevalence of tetracycline resistance in N. gonorrhoeae worldwide, including the US and Western Europe, has been too high to rely on doxycycline or other tetracyclines in treating gonorrhea. The rise in prevalence of tetracycline resistance in MSM, the main population in whom doxy-PEP is indicated (roughly from 10-20% to 40-50% recently) bears very close watching, and we must not be complacent about the potential for resistance in other STI pathogens (e.g....