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Have the HYPERION and ZENITH trial data changed how you sequence sotatercept in a newly diagnosed patient with intermediate-to-high-risk WHO Group 1 PAH — specifically, do you now add sotatercept at diagnosis alongside background dual therapy rather than waiting for inadequate response?

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In light of HYPERION and ZENITH trial data, do you now add sotatercept at diagnosis alongside background dual therapy rather than waiting for inadequate response?

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