Have you found aripiprazole effective for treatment of psychosis and bipolar mania in practice?

In a 2023 article published in Focus by Keramatian et al., PMID 38695002, the International Society for Bipolar Disorders (ISBD) created guidelines for the treatment of bipolar disorder, and aripiprazole was considered to be a first-line treatment for acute mania.

From my read (I'll admit, I read the...

While aripiprazole is approved for schizophrenia, I rarely use it for treating this condition. I do not find that it is effective enough to treat true psychotic symptoms when compared to almost all other SGAs. The same goes for bipolar mania. Instead, I tend to use aripiprazole for less severe cases...

I work in a first-episode psychosis coordinated specialty care clinic, and I use aripiprazole frequently for both schizophrenia and bipolar I disorder. I agree it can be less rapidly effective for acute positive symptoms of psychosis or acute symptoms of mania than some other antipsychotics because ...

It is highly case-dependent. In more moderate to severe cases of either, I have some reservations. We use a lot of long-acting injectables at my academic hospital, including aripiprazole. Over the years, I have had a number of cases who were readmitted and were apparent aripiprazole failures. If the...