Have you utilized a dose-reduced approach for elderly patients receiving frontline Pola-R-CHP, similar to R-miniCHOP?

I have utilized a dose-reduced approach for Pola-R-CHP for patients who are elderly, whom I would normally treat with R-miniCHOP, based on the early safety data from the POLAR BEAR trial. This randomized trial compared pola-r-miniCHP to R-miniCHOP in patients >80 years of age or >/=75 with comorbid ...

I have used it in patients who had already started on Pola-R CHP but developed toxicities; I have not used it as an initial regimen. The interim analysis of the POLAR BEAR trial (EHA 2026) was presented, focusing on preliminary safety. Pola-R Mini CHP had slightly more infections and GI toxicity. We...